Topic: Mesenchymal stem cells (MSCs) possess the immunological properties which make them promising candidates in regenerative medicine by Paige Adams FNP-BC and Jeff Bradstreet MD
The Once and Future Cure:Past Present and Future of Medicine - Nashville, TN - March 14-16, 2014
Mesenchymal stem cells (MSCs) possess the immunological properties which make them promising candidates in regenerative medicine. MSC therapy may be applicable to several diseases associated with inflammation and tissue damage, where subsequent regeneration and repair is necessary. MSCs could exert a positive effect in a variety of disorders through the following mechanisms: stimulation of repair in the damaged tissue, e.g., inflammatory bowel disease, cardiovascular disease, neurodegenerative; synthesizing and releasing anti-inflammatory cytokines and survival-promoting growth factors; integrating into existing neural and synaptic network, and restoring plasticity, rebuilding myocardium and vascular flow. The paracrine mechanisms of MSCs show interesting potential in restorative treatments. Promising and impressive results have been reported from the few clinical studies published to date, although the exact mechanisms of action of MSCs in restoring functions are still largely unknown for neurological disorders. The potential role of MSCs in mediating recovery will be discussed in light of the newest findings from recent clinical studies.
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