Thomas Seyfried PhD - Cancer as a Mitochordrial Metabolic Disea


Topic: Cancer as a Mitochordrial Metabolic Disease: Implications for Novel Therapeutics by Thomas Seyfried PhD

Conference: Energy and Medicine: Paradox & Controversy - Chicago, IL - Oct. 30 - Nov. 1, 2015

Summary: Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Cancer is suppressed following transfer of the nucleus from the tumor cell to cytoplasm of normal cells containing normal mitochondria. These findings indicate that nuclear genetic abnormalities alone cannot be responsible for cancer despite commonly held beliefs in the cancer field. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria. Cancer growth and progression can be managed following a whole-body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. This transition, facilitated using calorie restricted ketogenic diets, will reduce tumor vascularity and inflammation while enhancing tumor cell death. A novel “press-pulse” therapeutic strategy is in development for the non-toxic metabolic management of cancer. Malignant brain cancer in preclinical models and humans will be used to illustrate general concepts. As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.

Learning Objectives
1. Attendees will understand that cancer arises from evidence based impairment respiration rather than from nuclear gene mutations
2. Attendees will learn that the damage to cellular respiration leads to evidence based compensatory fermentation, which drives cancer cell growth and disease progression
3. Attendees will be informed that the Glucose/Ketone Index (GKI) can predict evidence based therapeutic efficacy of metabolic therapy for brain cancer
4. Attendees will be able to recognize the “Press-Pulse Paradigm” as evidence based therapeutic strategy for the metabolic management of cancer involving ketogenic diets, non-toxic drugs, and hyperbaric oxygen therapy

Time: 56 mins.

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