Topic: The Under-Appreciated Role of the GI Metabolome by David Quig PhD
A Gut Feeling - Atlanta, GA - March 2 - 6, 2016
The gastrointestinal (GI) metabolome has a huge role in detoxification of xenobiotic chemical entities and metals. This presentation will elucidate the numerous clinically relevant mechanisms by which the metabolic activity of the microbiome adversely affects innate detoxification. In addition, a brief overview of the revolutionary evidence-based proteomic method of identification of gastrointestinal microbes will be presented. The GI metabolome affects detoxification in the gut as well as systemically. Microbial metabolites and their cellular constituents can impact the capacity of all three phases of hepatic detoxification, arsenic detoxification, and inflammation and oxidative stress. There are at least three ways that a dysbiotic gut can adversely affect methionine metabolism (methylation and transsulfuration) that is central to detoxification, and the quenching of reactive oxygen species (ROS). The increased ROS further perpetuate a viscous cycle of disruption. The competing roles of Nrf2, and its’ evil twin Nf-kB, will be highlighted and phytonutrient intervention will be discussed as a means to restore detoxification and cellular adaptive responses that are mediated by the Nrf2-ARE signaling pathway. In the latter regard the importance of supporting “healthy” levels of Lactobacilli, and other beneficial/commensal bacteria will be emphasized. The information presented will enable practitioners to apply the principles immediately in clinical practice.
1. Explain the numerous ways by which a dysbiotic gastrointestinal microbiome can significantly compromise systemic innate detoxification processes.
2. Explain how to use objective laboratory tests to evaluate the status of innate detoxification, and identify root causes of bottlenecks in the biochemical processes.
3. Explain the evidence-based fundamentals involved in the revolutionary proteomic method of identification of gastrointestinal microbes.
4. Identify the gut-derived mechanisms associated with the balance between Nf-kB and Nrf2 as it affects gastrointestinal and systemic inflammation and immune function.
5. Integrate the relationships among the gastrointestinal metabolome, short-chain fatty acids, amino acid metabolism and intracellular signaling pathways in the optimization of innate detoxification.
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