Andrea Gruszecki - Environmental exposures and neurotransmitter


Topic: Environmental exposures and neurotransmitter disruptions-Everyday exposures, oxidative stress and neurodegeneration by Andrea Gruszecki, ND

Conference: Neurodegeneration: The Impact of Environmental Insult - Grand Rapids, MI - October 4 - 8, 2017

The presentation will review a variety of environmental exposures that may alter neurotransmission and increase neurodegeneration and the use of urinary neurotransmitter assessments as a clinical tool in the evaluation and monitoring neurotransmission, environmental exposures and detoxification.

Urinary neurotransmitters may serve as functional biomarkers for the enzymes of neurotransmission. Increased oxidative stress from environmental exposures may contribute to neurodegenerative disorders. Changes in urinary serotonin, dopamine, and glutamate levels have been suggested as biomarkers in neurobehavioral toxicology to assess symptoms from chemical or toxic element exposures. Information gained through neurotransmitter assessments may provide therapeutic opportunities that improve clinical success and patient health outcomes. Neurotransmitter metabolism requires a variety of enzymes, including catechol-O-methyltransferase (COMT), monoamine oxidase (MAO). Patterns of neurotransmitters and their metabolites may provide functional information about these important detoxification enzymes. Altered patterns of urinary neurotransmitters may also highlight the need for precursor amino acids or nutritional cofactors essential for neurotransmitter synthesis and metabolism. Strategies for the assessment of neurotransmitters and precursor nutrients vital for normal neurologic function will be summarized. Nutritional support that may optimize the function of neurotransmission enzymes, support normal neurologic functions and decrease oxidative stress will be reviewed.

Educational Objectives:
Increased familiarity with neurotransmitter synthesis and metabolism and the metabolism of neurotransmitters and the integral roles of COMT and MAOA in detoxification.
Increased familiarity the effects toxicant exposures may have on enzymes of neurotransmission, neurologic functions, and neurodegeneration.
Increased familiarity with nutritional supports for neurotransmitter synthesis and metabolism.

Time: 57 mins.

File Type: Down-loadable Zip file including MP3 audio file and PDF slides.

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