Boyd Haley PhD - An evaluation of heavy metal chelation by vario

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Topic: Neurological Effects of airborne gases: xylene, hydrogen sulfate and others by Boyd Haley PhD

Conference: Neurodegeneration: The Impact of Environmental Insult - Grand Rapids, MI - October 4 - 8, 2017

Summary:Most currently available compounds used to treat animals and humans for heavy metal toxicity, primarily mercury and lead toxicity, are charged, hydrophilic compounds that are not effective at reaching the intracellular sites where most of the heavy metal is bound that causes the toxic effects. Some of these compounds have sulfhydryls on adjacent carbons that sterically prevent them from chelating Hg2+ in a 1;1 complex. Instead they form weaker sandwich complexes with Hg2+. Charged heavy metal complexes are excreted through the kidneys into the urine. In weaker binding complexes with Hg2+ the mercury being excreted can exchange with more reactive sulfhydryls on proteins in the kidney causing a deterioration of kidney function. Since these compounds are charged they do not effectively cross cell membranes or enter the central nervous system where the heavy metal binding and toxic effects are mostly occurring. They therefore mostly bind to blood located Hg2+ reducing the levels by about 25-30%. This reduction in blood Hg2+ levels is re-established quickly by equilibrium with the intracellular Hg body burden which is much larger. While this approach seems to work it takes many treatments over a long period of time to have a significant effect on total mercury body burden. There is also a concern about translocation of Hg2+ into the kidney causing renal deterioration. Recently, a new class of uncharged, hydrophobic chelator has been developed that enters cells, crosses the blood brain barrier and forms a true 1:1 chelate with Hg2+ that is very stable and non-reactive, and does not translocate Hg to other tissues. This new chelator has a structure that consists of two naturally occurring compounds used as food preservatives or antioxidants. The animal and human testing at levels effective and safe for chelation has little to no toxic side effects and does not cause a depletion in any essential metal. It has been tested and shown to be efficacious in preventing death and toxicity in animals subjected to multiple lethal dose of HgCl2 and in Phase II efficacy studies on mercury toxic miners with no significant adverse effects occurring. In a Phase I safety and pharmacokinetics study no significant adverse effects were recorded and no depletion of essential metals.

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